ith regard to the pill mass, plasticity should be understood as its ability to take the appropriate shape, that is, to roll out into a rod and then into balls. Simultaneously with plasticity, the pill mass should also have a definitely pronounced elasticity.
If the pill mass does not possess this property, but shows some tendency to softening, then during storage, under the influence of relatively weak deforming forces, the spherical shape of the pharmacy online. On the other hand, if the pill mass becomes too elastic, then it is difficult to roll it into a rod and prepare round bodies of the correct shape.
The ability of the pill mass to disintegrate in gastric (or intestinal) juice according to GPC refers to the ability of the pills rolled out of it to disintegrate in water or 0.5% hydrochloric acid solution at 37 ° C (with gentle rocking of the cone 1-2 times per second, avoiding shaking) within 1 hour. The specified properties of the pill mass are achieved by the appropriate selection of aids.
Serves for dissolving medicinal substances. In addition, the water converts the swellable substances into gels or sticky sols and thereby provides adhesion of the solid components of the pill mass. The basic rule is to try to prepare the pill mass first of all with the help of water. Other solvent or binders are used when they can produce a better quality mass than water.
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Serves for the treatment of resinous pill masses, since resins dissolve in ethanol or swell in it.
Plastifies pill masses that contain a large amount of solids better than water. Usually consumed as Aqua giycerinata (1: 1).
Sugar (beet and milk). Beet sugar is used in the form of simple syrup, sugar water (equal parts of syrup and water), as well as a mixture of syrup, glycerin and water (1: 1: 8); slows down drying... It can be used as a powder as a hydrophilic plasticizer. Milk sugar does not absorb water, but it makes the pills easier to disintegrate.
Plant extracts. The most commonly used thick licorice extract is a highly viscous hygroscopic liquid that plasticizes pill masses well and slows down their drying at the same time. When using dry liquorice extract, the addition of glycerin and glycerin water is required. Almost all medicinal substances (liquid, thick and dry) can be turned into pill masses using licorice extracts.
In this case, it is necessary to use root powder, otherwise the pills will disintegrate with difficulty.
Dense extracts of dandelion, wormwood, and valerian root are also good binders suitable for making many pill masses. However, these extracts must be considered both adjuvans (bitterness) and medicinal substances (valerian extract) at the same time.
Herbal powders. Powders of licorice root, dandelion, wormwood, valerian root are always accompanied in pills with the extracts of the same name. Other plant powders, such as marshmallow powder, can also be added to the composition of the pill masses. All plant powders contain both soluble or water-swollen substances and insoluble solid particles of plant tissues. Therefore, they can be in the liquid and solid phases of the pill mass.
The above applies equally to rosehip and wheat flour. Rosehip fruits (pulp) contain many pectin substances, which swell in the presence of water and bind the incoming ingredients well, resulting in a plastic and sufficiently elastic pill mass. The high swelling capacity due to the presence of gluten in wheat flour and its high elasticity make it possible to prepare pills even from pill masses that are difficult to process.
Starch (potato, wheat, maize). It is mainly used in the manufacture of pills from extracts and highly viscous liquids. It enters the mass as a solid phase. At body temperature, starch swells noticeably, so pills containing it disintegrate more easily. Starch is good to combine with glucose and sugar.
Mineral powders (bentonite, white clay, aluminum hydroxide, aerosil). They are distinguished by their ability to absorb liquids (water, oils). They act on the mass as drying substances, imparting greater hardness to the pills after drying. They are widely used in cases where the composition of the pills contains substances that are easily decomposed in the presence of organic substances.
Based on the properties and role in the pill mass, all of the listed excipients can be divided into three groups:
1) solvents and liquid components that maintain the required moisture content of the pills and have weak binding properties (water, ethanol, glycerin and their mixtures);
2) substances, emulsifying liquids and gluing hydrophobic solid particles (plant extracts, wheat flour, rose hips in powder);
3) powdery substances that compact the mass to a plastic state and reduce elasticity (vegetable powders, starch, sugar, starch-sugar mixtures, aerosil and other mineral powders).